Caracterización clínico-epidemiológica de pacientes pediátricos con COVID-19 atendidos en un hospital regional de El Salvador
Resumen
OBJETIVO: Describir las características epidemiológicas, clínicas, de laboratorio, imagen y tratamiento de casos pediátricos de COVID-19, confirmados por reacción en cadena de polimerasa-transcriptasa reversa (RT PCR) o serología, atendidos en un hospital regional de El Salvador.
MATERIALES Y MÉTODOS: Estudio transversal y descriptivo de pacientes pediátricos con COVID-19, confirmados con pruebas moleculares o serología atendidos entre el 1 de junio y el 31 de diciembre de 2020. Para asegurar la confidencialidad se asignó un código por paciente.
RESULTADOS: Se estudiaron 72 pacientes entre los que predominó el grupo de 1 a 4 años (n = 25). La media de edad fue de 3.4 años; 28 de sexo femenino y 44 del masculino. Permanecieron asintomáticos 3 pacientes, 37 con síntomas leves, 22 moderados, 4 graves y 6 críticos. Los síntomas más frecuentes fueron: fiebre, hiporexia, adinamia y tos. Los hallazgos de laboratorio de mayor reporte fueron: anemia, linfopenia, deshidrogenasa láctica, proteína C reactiva y velocidad de eritrosedimentación elevadas. En la radiografía de tórax se encontró neumonía en 26 pacientes. Tratamientos más indicados: antibióticos y acetaminofén. Once pacientes requirieron oxígeno suplementario y siete ventilación mecánica. La estancia hospitalaria en menores de 1 año fue del doble con respecto a los otros grupos etarios. Seis pacientes resultaron con síndrome inflamatorio multisistémico. Hubo siete fallecimientos.
CONCLUSIONES: Si bien en la mayoría de los casos el pronóstico fue favorable, algunos pacientes tuvieron enfermedad grave o crítica y fallecieron a pesar de su atención en cuidados intensivos. Para disminuir estos desenlaces se requiere educar a la población a fin de que acuda rápidamente a consulta, fortalecer las competencias clínicas del personal de salud para la identificación oportuna de la enfermedad e incrementar la capacidad instalada de cuidados intensivos ante fenómenos epidemiológicos similares.
Citas
World Health Organization. Coronavirus disease (COVID-19) pandemic, WHO. 2022. Disponible en: https://www.who.int/emergencies/diseases/novel-coronavirus-2019?adgroupsurvey={adgroupsurvey}&gclid=Cj0KCQjwhLKUBhDiARIsAMaTLnEW8xXi4_sywpOtmPBzMd0YAKD8FwcGpmlSVjCuU7BEAFV3-Rk5axAaArajEALw_wcB
World Health Organization. WHO Coronavirus (COVID-19) Dashboard. WHO. 2021. Disponible en: https://covid19.who.int/?gclid=Cj0KCQjwlOmLBhCHARIsAGiJg7mwYVOy6SDAWogC5R3qu85k9QODCcxHQrrspmostTPJjsganhJBb68aAng_EALw_wcB
Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, et al. Epidemiology of COVID-19 Among Children in China. Pediatrics. 2020;145(6): e20200702. DOI: 10.1542/peds.2020-0702
Shen KL, Yang YH, Jiang RM, Wang TY, Zhao DC, Jiang Y, et al. Updated diagnosis, treatment and prevention of COVID-19 in children: experts' consensus statement (condensed version of the second edition). World J Pediatr. 2020;16(3):232-239. DOI: 10.1007/s12519-020-00362-4
Tagarro A, Epalza C, Santos M, Sanz-Santaeufemia FJ, Otheo E, Moraleda C, et al. Screening and Severity of Coronavirus Disease 2019 (COVID-19) in Children in Madrid, Spain. JAMA Pediatr. 2020; e201346. DOI: 10.1001/jamapediatrics.2020.1346
Ministerio de Salud de El Salvador. Lineamientos técnicos para la atención integral de personas con COVID-19. Segunda edición. Minsal. Agosto 2020. Disponible en: http://asp.salud.gob.sv/regulacion/pdf/lineamientos/lineamientos_tecnicos_atencion_integral_codiv19_segunda_edicion_adenda_acuerdo_1949.pdf
Acevedo L, Piñeres-Olave BE, Niño-Serna LF, Vega LM, Gomez IJA, Chacón S, et al. Mortality and clinical characteristics of multisystem inflammatory syndrome in children (MIS-C) associated with covid-19 in critically ill patients: an observational multicenter study (MISCO study). BMC Pediatr. 2021;21(1):516. DOI: 10.1186/s12887-021-02974-9
Pereira MFB, Litvinov N, Farhat SCL, Eisencraft AP, Gibelli MABC, Carvalho WB, et al. Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome. Clinics. 2020;75:e2209. DOI:10.6061/clinics/2020/e2209
Feldstein LR, Rose EB, Horwitz SM, Collins JP, Newhams MM, Son MBF, et al. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N. Engl. J. Med. 2020;383(4):334–346. DOI:10.1056/NEJMoa2021680
Rubens JH, Akindele NP, Tschudy MM, Sick-Samuels AC. Acute covid-19 and multisystem inflammatory syndrome in children. BMJ. 2021:n385. DOI:10.1136/bmj.n385
American Academy of Pediatrics. Children and COVID-19: State-Level Data Report. AAP Home. 2022. Available from: https://www.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/children-and-covid-19-state-level-data-report/
Dewi R, Kaswandani N, Karyanti MR, Setyanto DB, Pudjiadi AH, Hendarto A, et al. Mortality in children with positive SARS-CoV-2 polymerase chain reaction test: Lessons learned from a tertiary referral hospital in Indonesia. Int J Infect Dis. 2021;107:78–85. DOI: 10.1016/j.ijid.2021.04.019
Whittaker E, Bamford A, Kenny J, Kaforou M, Jones CE, Shah P, et al. Clinical Characteristics of 58 Children with a Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2. JAMA. 2020;324(3):259. DOI: 10.1001/jama.2020.10369
Ouldali N, Pouletty M, Mariani P, Beyler C, Blachier A, Bonacorsi S, et al. Emergence of Kawasaki disease related to SARS-CoV-2 infection in an epicentre of the French COVID-19 epidemic: a time-series analysis. Lancet Child Adolesc Health. 2020;4(9):662–8. DOI: 10.1016/S2352-4642(20)30175-9
Swann OV, Holden KA, Turtle L, Pollock L, Fairfield CJ, Drake TM, et al. Clinical characteristics of children and young people admitted to hospital with Covid-19 in United Kingdom: prospective multicentre observational cohort study. BMJ. 2020;m3249. DOI: 10.1136/bmj.m3249
Cifuentes MP, Rodriguez-Villamizar LA, Rojas-Botero ML, Alvarez-Moreno CA, Fernández-Niño JA. Socioeconomic inequalities associated with mortality for COVID-19 in Colombia: a cohort nationwide study. J. Epidemiol. Community Health. 2021;75(7):610–615. DOI:10.1136/jech-2020-216275
Mena GE, Martinez PP, Mahmud AS, Marquet PA, Buckee CO, Santillana M. Socioeconomic status determines COVID-19 incidence and related mortality in Santiago, Chile. Science. 2021;372(6545):eabg5298. DOI:10.1126/science.abg5298
Zampieri FG, Skrifvars MB, Anstey J. Intensive care accessibility and outcomes in pandemics. Intensive Care Med. 2020;46(11):2064–2066. DOI:10.1007/s00134-020-06264-3
Silva LL. Emergency Care Gap in Brazil: Geographical Accessibility as a Proxy of Response Capacity to Tackle COVID-19. Front Public Health. 2021;9:740284. DOI:10.3389/fpubh.2021.740284
Levy M, Recher M, Hubert H, Javouhey E, Fléchelles O, Leteurtre S, et al. Multisystem Inflammatory Syndrome in Children by COVID-19 Vaccination Status of Adolescents in France. JAMA. 2022;327(3):281-283. DOI: 10.1001/jama.2021.23262
Payne AB, Gilani Z, Godfred-Cato S, Belay ED, Feldstein LR, Patel MM, et al. Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2. JAMA Netw Open. 2021;4(6):e2116420. DOI: 10.1001/jamanetworkopen.2021.16420
Feldstein LR, Tenforde MW, Friedman KG, Newhams M, Rose EB, Dapul H, et al. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA. 2021;325(11):1074-1087. DOI: 10.1001/jama.2021.2091
Centers for Disease Control and Prevention. Information for Healthcare Providers about Multisystem Inflammatory Syndrome in Children (MIS-C). CDC. 2021. Disponible en: https://www.cdc.gov/mis/mis-c/hcp/index.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fmis%2Fhcp%2Findex.html
Centers for Disease Control and Prevention. COVID-19 Response Team. Coronavirus disease 2019 in children — United States, February 12–April 2, 2020. Morbidity and Mortality Weekly Report 422 MMWR. 2020;69(14):422–6. Disponible en: https://www.cdc.gov/mmwr/volumes/69/wr/pdfs/mm6914e4-H.pdf
Seth S, Rashid F, Khera K. An overview of the COVID‐19 complications in paediatric population: A pandemic dilemma. Int. J. Clin. Pract. 2021;75(9). DOI:10.1111/ijcp.14494
Siebach MK, Piedimonte G, Ley SH. COVID‐19 in childhood: Transmission, clinical presentation, complications and risk factors. Pediatr. Pulmonol. 2021;56(6):1342–1356. DOI:10.1002/ppul.25344
Siracusa L, Cascio A, Giordano S, Medaglia AA, Restivo GA, Pirrone I, et al. Neurological complications in pediatric patients with SARS-CoV-2 infection: a systematic review of the literature. Ital. J. Pediatr. 2021;47(1):123. DOI:10.1186/s13052-021-01066-9
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-1069. DOI: 10.1001/jama.2020.1585
Kelada M, Anto A, Dave K, Saleh SN. The Role of Sex in the Risk of Mortality from COVID-19 Amongst Adult Patients: A Systematic Review. Cureus. 2020;12(8):e10114. DOI: 10.7759/cureus.10114
Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, et al. SARS-CoV-2 Infection in Children. N Engl J Med. 2020;382(17):1663–5. DOI: 10.1056/NEJMc2005073
Götzinger F, Santiago-García B, Noguera-Julián A, Lanaspa M, Lancella L, Caló Carducci FI, et al. COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study. Lancet Child Adolesc Health. 2020; 4(9): 653-661. DOI: 10.1016/S2352-4642(20)30177-2
Zhu L, Wang J, Huang R, Liu L, Zhao H, Wu C, et al. Clinical characteristics of a case series of children with coronavirus disease 2019. Pediatr Pulmonol. 2020; 55(6): 1430-1432. DOI: 10.1002/ppul.24767
Katz J, Guelmann M. Increased Prevalence of Dysgeusia in Pediatric Patients Diagnosed with COVID-19. Pediatr Dent. 2021;43(4):282-284. PMID: 34467844
Yan Q, Qiu D, Liu X, Guo X, Hu Y. Prevalence of Smell or Taste Dysfunction Among Children With COVID-19 Infection: A Systematic Review and Meta-Analysis. Front Pediatr. 2021;9:686600. DOI: 10.3389/fped.2021.686600. eCollection 2021
Mania A, Mazur-Melewska K, Lubarski K, Kuczma-Napierała J, Mazurek J, Jończyk-Potoczna K, et al. Wide spectrum of clinical picture of COVID-19 in children — From mild to severe disease. J Infect Public Health. 2021;14(3):374-379. DOI: 10.1016/j.jiph.2020.12.029
Epidemiology Working Group for NCIP Epidemic Response, Chinese Center for Disease Control and Prevention. [The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2020;41(2):145-151. DOI: 10.3760/cma.j.issn.0254-6450.2020.02.003.3
Wardlaw T, Salama P, Johansson EW, Mason E. Pneumonia: the leading killer of children. Lancet. 2006;368(9541):1048-50. DOI: 10.1016/S0140-6736(06)69334-3
Wang Z, Li X, Li D, Li Y. Clinical features of 167 children with the novel influenza A (H1N1) virus infection in Xian, China. Turk J Pediatr. 2012; 54(2): 99-104. PMID: 22734294
Babyn PS, Chu WC, Tsou IY, Wansaicheong GK, Allen U, Bitnun A, et al. Severe acute respiratory syndrome (SARS): chest radiographic features in children. Pediatr Radiol. 2004;34(1):47-58. DOI: 10.1007/s00247-003-1081-8
Prata-Barbosa A, Lima-Setta F, Santos GRD, Lanziotti VS, de Castro REV, de Souza DC, et al. Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study. J Pediatr (Rio J). 2020;96(5):582-592. DOI: 10.1016/j.jped.2020.07.002
Shekerdemian LS, Mahmood NR, Wolfe KK, Riggs BJ, Ross CE, McKiernan CA, et al. Characteristics and Outcomes of Children with Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units. JAMA Pediatr. 2020;174(9):868-873. DOI: 10.1001/jamapediatrics.2020.1948
Liu X, Tang J, Xie R, Li W, Chen J, Guo Y, et al. Clinical and Epidemiological Features of 46 Children <1-Year-Old with Coronavirus Disease 2019 in Wuhan, China: A Descriptive Study. J Infect Dis. 2020;222(8):1293-1297. DOI: 10.1093/infdis/jiaa472
Zhang C, Gu J, Chen Q, Deng N, Li J, Huang L, et al. Clinical and epidemiological characteristics of pediatric SARS-CoV-2 infections in China: A multicenter case series. PLoS Med. 2020;17(6):e1003130. DOI: 10.1371/journal.pmed.1003130
Guo CX, He L, Yin JY, Meng XG, Tan W, Yang GP, et al. Epidemiological and clinical features of pediatric COVID-19. BMC Med. 2020;18(1):250. DOI: 10.1186/s12916-020-01719-2
Garazzino S, Montagnani C, Doná D, Meini A, Felici E, Vergine G, et al. Multi-centre Italian study of SARS-CoV-2 infection in children and adolescents, preliminary data as at 10 April 2020. Euro Surveill. 2020;25(18):2000600. DOI: 10.2807/1560-7917.ES.2020.25.18.200600