The prevalence of hyperglycemia in neonatal hypernatremic dehydration (NHD) and its correlation with prognosis in exclusively breastfed infants: A cohort study

Hassan Boskabadi; Maryam Zakerihamidi

doi:10.18233/APM41No6pp249-2561772

Hassan Boskabadi
Maryam Zakerihamidi

DOI: https://doi.org/10.18233/APM41No6pp249-2561772

Resumen

BACKGROUND: Glucose changes are unknown in neonatal dehydration with hypernatremia.

OBJECTIVE: Was to investigate glucose status in neonatal hypernatremic dehydration (NHD) and its correlation with NHD prognosis.

MATERIAL AND METHODS: In this cohort study, serum glucose of 172 neonatal hypernatremic dehydration infants admitted to the Ghaem Hospital in Mashhad, Iran, was reviewed within the time frame of 2012 to 2017. The data were collected utilizing a questionnaire designed by the researchers to describe the characteristics of the mothers and neonates, as well as their laboratory and imaging study results. The neonatal hypernatremic dehydration infants were followed using the Denver Developmental Test II (DDT II) questionnaire at follow-up months 6, 12, 18, 24, 30, and 36.

RESULTS: 134 infants (77.91%) had normal blood glucose levels and 38 infants (22.09%) had a hyperglycemic status. In both groups, the differences in infant age (p = 0.000), weight upon admission (p = 0.035), breastfeeding duration (p = 0.003), frequency of urination (p = 0.001), blood sugar (p = 0.000), sodium (p = 0.008), urea (p = 0.000), creatinine (p = 0.000), and pH upon admission (p = 0.002) were statistically significant. Developmental delays were higher in the neonatal hypernatremic dehydration group with hyperglycemia (p = 0.029). There was a significant correlation between sodium levels and blood sugar (p = 0.000).

CONCLUSION: According to our study results, hyperglycemic neonatal hypernatremic dehydration infants had an older referral age; higher sodium, urea, and creatinine levels; lower weight upon admission; shorter breastfeeding duration; lower frequency of urination; and lower blood pH. Therefore, checking the blood sugar of infants with hypernatremia is recommended and high serum glucose is a poor prognosis criterion in infants with neonatal hypernatremic dehydration.