Graft versus host disease in a patient with chronic granulocytic leukemia who received an hematopoietic progenitor cell transplant

  • Marta Zapata-Tarrés Instituto Nacional de Pediatría
  • Eduardo López-Corella Instituto Nacional de Pediatría
  • Martín Pérez-García Instituto Nacional de Pediatría
  • Roberto Rivera-Luna Instituto Nacional de Pediatria

Resumen

Male patient age 6 years 9 months, native of the State of Mexico,
without relevant antecedents. Parents age 32 years, with highschool
level education, merchants; subject has a brother age 10
years and a sister age 4 years. His government vaccination plan
is complete. Two months ago he presented onset of fever, epistaxis,
and splenomegaly. At Hospital Materno Infantil de Toluca
the blood biometry reported: hemoglobin 8.8 g/dL, hematocrit
24%, leukocytes 230,500/mm3, neutrophils 21%, bands 34%,
lymphocytes 9%, monocytes 7%, blasts 14%, basophils 11%,
eosinophils 4%. An analysis found: serum creatinine and liver
function tests normal.

Biografía del autor/a

Marta Zapata-Tarrés, Instituto Nacional de Pediatría
Oncology Service
Eduardo López-Corella, Instituto Nacional de Pediatría
Department of Pathology.
Martín Pérez-García, Instituto Nacional de Pediatría
Transplant Service.
Roberto Rivera-Luna, Instituto Nacional de Pediatria
Hemato-Oncology Division.

Citas

Castro-Malespina H, Schaison G, Briere J, Passe S, Pasquier

A, et al. Philadelphia chromosome-positive chronic myeloid

leukemia in children: survival and prognostic features.

Cancer 1983;52:721.

Gartner JG. Thymic involution with loss of Hassall’s

corpuscles mimicking thymic dysplasia in a child with

transfusion-associated graft-versus-host disease. Pediatr

Pathol 1991;11:449-456.

Hughes TP, Hochhaus A, Bradford S, Muller MC, Kaeda JS,

et al. Long-term prognostic significance of early molecular

response to imatinib in neuly diagnosed chronic myeloid

leukemia. Blood 2010;116:3758-3765.

Lichtman MA. Is There an entity of chemically induced

BCR-ABL–positive chronic myelogenous leukemia? The

Oncologist 2008;13:645-654.

Ortiz-Hidalgo C. Notas sobre la historia de la leukemia.

Patologia 2013;51:58-89.

Rowley JD. A new consistent chromosomal abnormality

in chronic muelogenous leukaemia identified by

quinacrine fluoresence and Giensa staining. Nature

;1:290-293.

Vigneri P, Wang JY. Induction of apoptosis in chronic myeloid

leukemia cells through nuclear entrapment of BCR-ABL

tyrosin kinase. Nat Med 2001;7:228-234.

Publicado
2014-07-09
Cómo citar
Zapata-Tarrés, M., López-Corella, E., Pérez-García, M., & Rivera-Luna, R. (2014). Graft versus host disease in a patient with chronic granulocytic leukemia who received an hematopoietic progenitor cell transplant. Acta Pediátrica De México, 35(1), 45-54. https://doi.org/10.18233/APM35No1pp39-47
Sección
Caso de sesión anatomo-clínica