Graft versus host disease in a patient with chronic granulocytic leukemia who received an hematopoietic progenitor cell transplant

Marta Zapata-Tarrés, Eduardo López-Corella, Martín Pérez-García, Roberto Rivera-Luna

Resumen


Male patient age 6 years 9 months, native of the State of Mexico,
without relevant antecedents. Parents age 32 years, with highschool
level education, merchants; subject has a brother age 10
years and a sister age 4 years. His government vaccination plan
is complete. Two months ago he presented onset of fever, epistaxis,
and splenomegaly. At Hospital Materno Infantil de Toluca
the blood biometry reported: hemoglobin 8.8 g/dL, hematocrit
24%, leukocytes 230,500/mm3, neutrophils 21%, bands 34%,
lymphocytes 9%, monocytes 7%, blasts 14%, basophils 11%,
eosinophils 4%. An analysis found: serum creatinine and liver
function tests normal.

Palabras clave


graft versus host disease; chronic leukemia; stem cell transplant;

Texto completo:

PDF (English)

Referencias


Castro-Malespina H, Schaison G, Briere J, Passe S, Pasquier

A, et al. Philadelphia chromosome-positive chronic myeloid

leukemia in children: survival and prognostic features.

Cancer 1983;52:721.

Gartner JG. Thymic involution with loss of Hassall’s

corpuscles mimicking thymic dysplasia in a child with

transfusion-associated graft-versus-host disease. Pediatr

Pathol 1991;11:449-456.

Hughes TP, Hochhaus A, Bradford S, Muller MC, Kaeda JS,

et al. Long-term prognostic significance of early molecular

response to imatinib in neuly diagnosed chronic myeloid

leukemia. Blood 2010;116:3758-3765.

Lichtman MA. Is There an entity of chemically induced

BCR-ABL–positive chronic myelogenous leukemia? The

Oncologist 2008;13:645-654.

Ortiz-Hidalgo C. Notas sobre la historia de la leukemia.

Patologia 2013;51:58-89.

Rowley JD. A new consistent chromosomal abnormality

in chronic muelogenous leukaemia identified by

quinacrine fluoresence and Giensa staining. Nature

;1:290-293.

Vigneri P, Wang JY. Induction of apoptosis in chronic myeloid

leukemia cells through nuclear entrapment of BCR-ABL

tyrosin kinase. Nat Med 2001;7:228-234.




DOI: http://dx.doi.org/10.18233/APM35No1pp39-47

Enlaces refback

  • No hay ningún enlace refback.