Frequency of risk infections for congenital infection in pregnant women

  • Heriberto Caballero-Ortega Instituto Nacional de Pediatría http://orcid.org/0000-0003-4269-8251
  • Luz Belinda Ortiz-Alegría Instituto Nacional de Pediatría http://orcid.org/0000-0002-0681-780X
  • Ana Laura Castañeda-Huitrón Instituto Nacional de Pediatría
  • Chiharu Murata Instituto Nacional de Pediatría
  • Ricardo Figueroa-Damián Instituto Nacional de Perinatología
  • María Dolores Correa Beltrán Instituto Nacional de Pediatría

Resumen

BACKGROUND: TORCH and other infections can be vertically transmitted and provoke abortions or result in congenitally infected newborns. Most babies are born with subclinical infection but have a high risk of developing sequalae later.

OBJECTIVE: To determine the frequency of seven endemic infections that represent risk for vertical transmission among pregnant women of a tertiary care hospital.

MATERIALS AND METHODS: Prospective, cross-sectional study carried out in pregnant women attended at the INPer between 2010 and 2012. Infections were investigated by serological risk markers among pregnant women living in the Valley of Mexico and answered a questionnaire including risk factors.

RESULTS: A total of 1079 pregnant women were studied, and the overall frequency of infection was 5.7%. Anti-Toxoplasma gondii low avidity IgG (2.0%) and parvovirus B19 IgM (2.0%) were the most common. No HBV S-Ag and one rubella case were detected. An association of markers studied with fetal malformations and transfusions (p < 0.015) was found. Toxoplasma infection was associated with the last two variables, as well as with the consumption of raw meat, previous positive TORCH and infection with HPV. Parvovirus B19 IgM was associated with stillbirths, and T. pallidum with HIV. Four cases had double infections.

CONCLUSIONS: This study supports the success of vaccination control programs against rubella and active HBV, although infections or perinatal risk are still challenging for this group of women and their children´s health.

Biografía del autor/a

Heriberto Caballero-Ortega, Instituto Nacional de Pediatría

Investigador en Ciencias Médicas

Laboratorio de Inmunología Experimental

Luz Belinda Ortiz-Alegría, Instituto Nacional de Pediatría

Investigadora en Ciencias Médicas

Laboratorio de Inmunología Experimental

Ana Laura Castañeda-Huitrón, Instituto Nacional de Pediatría
Laboratorio de Inmunología Experimental
Chiharu Murata, Instituto Nacional de Pediatría

Investigador en Ciencias Médicas

Departamento de Metodología de la Investigación

Ricardo Figueroa-Damián, Instituto Nacional de Perinatología
Servicio de Infectología
María Dolores Correa Beltrán, Instituto Nacional de Pediatría

Investigadora en Ciencias Médicas

Laboratorio de Inmunología Experimental

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Publicado
2021-05-11
Cómo citar
Caballero-Ortega, H., Ortiz-Alegría, L., Castañeda-Huitrón, A., Murata, C., Figueroa-Damián, R., & Correa Beltrán, M. (2021). Frequency of risk infections for congenital infection in pregnant women. Acta Pediátrica De México, 42(3), 102-111. https://doi.org/10.18233/APM42No3pp102-1112129
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